Нежелательные реакции, представленные ниже, перечислены в соответствии с поражением органов и систем органов и частотой встречаемости. Частота встречаемости определяется следующим образом: очень часто (≥1/10), часто (≥1/100 и <1/10), нечасто (≥1/1 000 и <1/100), редко (≥1/10 000 и <1/1000), очень редко (<1/10 000, включая отдельные случаи).
Нежелательные реакции, наблюдаемые «очень часто», «часто» и «нечасто», обычно определяли по данным клинических исследований. Частоту встречаемости при приеме плацебо также учитывали. Нежелательные реакции, наблюдаемые «редко» и «очень редко», определяли на основании спонтанных сообщений, полученных в рамках пострегистрационного наблюдения.
При приеме стандартных доз ондансетрона установлена частота встречаемости, представленная ниже.
Профиль нежелательных реакций у детей и подростков был сопоставим с профилем, наблюдаемым у взрослых.
Нарушения со стороны иммунной системы
Редко — реакции гиперчувствительности немедленного типа (крапивница, бронхоспазм, ларингоспазм, ангионевротический отек), в ряде случаев тяжелой степени, включая анафилаксию.
Нарушения со стороны нервной системы
Очень часто головная боль; нечасто судороги, двигательные расстройства (включая экстрапирамидные симптомы, такие как дистония, окулогирный криз и дискинезия) при отсутствии стойких клинических последствий; редко преимущественно во время быстрого внутривенного введения. головокружение,
Нарушения со стороны органа зрения
Редко преходящие расстройства зрения (например, затуманенное зрение), главным образом, во время внутривенного введения; очень редко транзиторная слепота, главным образом, во время внутривенного введения.
Нарушения со стороны сердца
Нечасто аритмия, боль в грудной клетке, как сопровождающаяся, так и не сопровождающаяся снижением сегмента ST, брадикардия; редко удлинение интервала QT (включая желудочковую тахикардию типа «пируэт»).
Нарушения со стороны сосудов
Часто чувство «жара» или «приливы»; нечасто снижение артериального давления.
Нарушения со стороны дыхательной системы, органов грудной клетки и средостения
Нечасто икота.
Нарушения со стороны желудочно-кишечного тракта
Часто — запор.
Нарушения со стороны печени и желчевыводящих путей
Нечасто бессимптомное повышение активности «печеночных» ферментов аланинаминотрансферазы (АЛТ), аспартатаминотрансферазы (АСТ) (в основном наблюдалось у пациентов, получающих химиотерапию цисплатином).
Нарушения со стороны кожи и подкожных тканей
Очень редко — токсическая кожная сыпь, включая токсический эпидермальный некролиз.
Общие расстройства и нарушения в месте введения (для лекарственной формы раствор для внутривенного и внутримышечного введения)
Часто — местные реакции при внутривенном введении жжение в месте введения.
Цена ВОМИСТОП АМП. 2МЛ №5 в Самарканде:
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Производитель:
RADIKS – Узбекистан
Срок годности этого товара:
01.11.2026
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4 mg/5 ml
Vomistop is a serotonin subtype 3 (5-HT3) receptor antagonist indicated:
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy.
- Prevention and treatment of post-operative nausea and vomiting.
- Prevention of radiotherapy-induced nausea and vomiting.
Vomistop oral soluble film is a orally dissolving film designed to be applied on top of the tongue where it will dissolve within 20 seconds and then is swallowed with saliva. Oral soluble film does not require water to aid dissolution or swallowing. The active ingredient in Vomistop is Vomistop base, the racemic form of Vomistop, and a selective blocking agent of the serotonin 5-HT3 receptor type. The empirical formula is C18H19N3O representing a molecular weight of 293.3.
Ondansetron is a potent, highly selective 5HT3 receptor-antagonist. Its precise mode of action in the control of nausea and vomiting is not known. Chemotherapeutic agents and radiotherapy may cause release of 5HT in the small intestine initiating a vomiting reflex by activating vagal afferents via 5HT3 receptors. Ondansetron blocks the initiation of this reflex. Activation of vagal afferents may also cause a release of 5HT in the area postrema, located on the floor of the fourth ventricle, and this may also promote emesis through a central mechanism. Thus, the effect of ondansetron in the management of the nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy is probably due to antagonism of 5HT3 receptors on neurons located both in the peripheral and central nervous system. The mechanisms of action in post-operative nausea and vomiting are not known but there may be common pathways with cytotoxic induced nausea and vomiting.
Chemotherapy-Induced Nausea and Vomiting-
Adults, Pediatric patients (6 months to 18 years):
- 8 mg tablet/orodispersible tablet: Three 0.15 mg/kg doses, up to a maximum of 16 mg per dose.
- 4 mg orodispersible tablet: Three 0.15 mg/kg doses, up to a maximum of 16 mg per dose.
- Injection: Three 0.15 mg/kg doses, up to a maximum of 16 mg per dose, infused intravenously over 15 minutes.
Radiotherapy-Induced Nausea and Vomiting-
Adults:
- 8 mg tablet/orodispersible tablet: Initial Dose: 8 mg orally 1 to 2 hours before radiotherapy. Post Radiotherapy: 8 mg orally every 8 hours for up to 5 days after a course of treatment.
- 4 mg orodispersible tablet: Three 0.15 mg/kg doses, up to a maximum of 16 mg per dose.
- Injection: Three 0.15 mg/kg doses, up to a maximum of 16 mg per dose, infused intravenously over 15 minutes.
Postoperative Nausea and Vomiting-
Adults:
- 8 mg tablet/orodispersible tablet: 16 mg given as two 8 mg tablets
- 4 mg orodispersible tablet: 16 mg
- Injection: 4 mg
Pediatrics (>40 kg): Injection: 4 mg
Pediatrics (40 kg): Injection: 0.1 mg/kg
Chemotherapy-induced Nausea and Vomiting-
Adults/Geriatric/Child of 12 years or over:
- Highly emetogenic cancer chemotherapy: 30 ml (24 mg) Ondansetron Oral Solution administered 30 minutes before start of emetogenic chemotherapy.
- Moderate emetogenic cancer chemotherapy: 10 ml (8 mg) Ondansetron Oral Solution administered 30 minutes before start of emetogenic chemotherapy. A further 10 ml dose should be administered after 8 hours of the first dose. One 10 ml dose should be administered twice a day (every 12 hours) for 1-2 days after completion of chemotherapy.
Pediatric (4-11 years): 5 ml (4 mg) Ondansetron Oral Solution should be taken 30 minutes before the start of chemotherapy. The other 2 doses should be taken 4 and 8 hours after the first dose. Then 5 ml oral solution should be administered 3 times a day (every 8 hours) for 1-2 days after completion of chemotherapy.
Oral solution:
Radiotherapy induced Nausea and Vomiting (Adults/Geriatric/Child of 12 years or over):
- The recommended oral dosage: 10 ml (8 mg) Ondansetron Oral Solution 3 times daily.
- For total body irradiation: 10 ml (8-mg) Ondansetron Oral Solution should be administered 1 to 2 hours before each fraction of radiotherapy administered each day.
- For single high-dose fraction radiotherapy to the abdomen: one 10 ml Ondansetron Oral Solution should be administered 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for 1 to 2 days after completion of radiotherapy.
- For daily fractionated radiotherapy to the abdomen: 10 ml (8-mg) Ondansetron Oral Solution should be administered 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for each day radiotherapy is given.
Postoperative Nausea and Vomiting (Adults/Geriatric/Child of 12 years or over):
- 20 ml (16 mg) Ondansetron Oral Solution 1 hour before induction of anesthesia
Oral Soluble Film:
Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy:
- Adult oral dose: 24 mg given successively as three 8 mg films 30 minutes before the start of chemotherapy.
Prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy:
- Adults and pediatric patients 12 years of age and older: One 8 mg film 30 minutes before chemotherapy followed by an 8 mg dose 8 hours later. Administer one 8 mg film twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy.
- Pediatric patients 4 through 11 years of age: One 4 mg film three times a day. Administer the first dose 30 minutes before chemotherapy, with subsequent doses 4 and 8 hours later. Administer one 4 mg film three times a day (every 8 hours) for 1 to 2 days after completion of chemotherapy.
- Prevention of nausea and vomiting associated with radiotherapy: The adult dosage is one 8 mg film three times a day.
- Postoperative nausea and vomiting: The adult dose is 16 mg given successively as two 8 mg films 1 hour before anesthesia.
Administration of Oral Soluble Film:
- Step 1: Tear the pouch carefully along with the edge tear mark.
- Step 2: Put the Ondansetron film on top of your tongue. It will dissolve within 20 seconds
- Step 3: Do not chew or swallow the film whole.
- Step 4: Swallow after the Onsaf oral soluble film dissolves. You may swallow the dissolved film with or without liquid.
- Step 5: Wash your hands after taking Onsaf oral soluble film
Vomistop does not itself appear to induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system of the liver. Because Vomistop is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes, inducers or inhibitors of these enzymes may change the clearance and hence, the half-life of Vomistop. On the basis of available data, no dosage adjustment of Ondasetron is recommended for patients on these drugs.
Contraindicated in patients known to have hypersensitivity to the drug or any of its components. Concomitant use of apomorphine.
Frequently reported adverse events were headache, constipation and diarrhea, but the majority have been mild or moderate in nature. In chemotherapy-induced nausea and vomiting, rash has occurred in approximately 1% of patients receiving Vomistop. There also have been reports to a sensation of flushing or warmth, hiccups and liver enzyme abnormalities. Rare cases of anaphylaxis, brochospasm, tachycardia, angina (chest pain), hypokalemia, shortness of breath have also been reported, except for bronchospasm and anaphylaxis, the relationship to Vomistop is unclear. There have been no evidence to extrapyramidal reactions, in rare case oculogyric crisis appearing alone, as well as with other dystonic reactions without definitive clinical evidence. In case of PONV, with the exception of headache, rates of these events were not significantly different in the Vomistop and placebo groups.
Carcinogenic effects were not seen in 2-year studies in rats and mice with oral Ondansetron doses up to 10 and 30 mg/kg per day, respectively. Ondansetron was not mutagenic in standard tests for mutagenicity. Oral administration of Ondansetron up to 15 mg/kg per day did not affect fertility or general reproduction performance of male and female rats.
Reproduction studies have been performed in pregnant rats and rabbits at daily oral doses up to 15 and 30 mg/kg per day, respectively, and have revealed no evidence of impaired fertility or harm to the fetus due to Ondansetron. There are, however, no adequate and well-controlled studies in pregnant women. Ondansetron is excreted in the breast milk of rats. So caution should be exercised when Ondansetron is administered to a nursing women.
Hypersensitivity reactions have been reported in patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists. Vomistop is not a drug that stimulates gastric or intestinal peristalsis. It should not be used instead of nasogastric suction. The use of Vomistop in patients following abdominal surgery or in patients with chemotherapy-induced nausea and vomiting may mask a progressive ileus and/or gastric distension.
Dosage Adjustment for Patients With Impaired Renal Function: The dosage recommendation is the same as for the general population.
Dosage Adjustment for Patients With Impaired Hepatic Function: In patients with severe hepatic impairment, a single maximal daily dose of 8 mg to be infused over 15 minutes beginning 30 minutes before the start of the emetogenic chemotherapy is recommended.
4 years of age or younger: Little information is available about dosage in pediatric patients 4 years of age or younger.
Over the age of 65: Dosage adjustment is not needed in patients over the age of 65.
Store at temperature not exceeding 30ºC in a dry place. Protect from light and moisture.
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Product Name
Vomistop (Domperidone 10mg) 500 Tablets/Pack
Our most popular generic domperidone
Active Ingredient
Domperidone 10mg
Manufacturer
Acme Generics LLP (Marketed by Cipla Ltd)
Product Type
Antiemetic, gastrokinetic
Product expiry date we are currently shipping
Jun 2026
Product appearance
October 2018: Presentation change — tablet darker, packaging slightly smaller. Same content and strength as before: Domperidone 10mg
Vomistop tablets 10mg contain domperidone, an antiemetic that prevents nausea and vomiting as well as relieving bloating and gastric discomfort, by blocking dopamine receptors in the brain and upper intestine.
Vomistop General Information
What is Vomistop used for?
Vomistop 10 is used to treat nausea and vomiting and help relieve symptoms like bloating, fullness, heartburn and flatulence that cause discomfort when the digestive system is out of rhythm or you have eaten too much. Vomistop 10 can also be used to relieve symptoms of nausea caused by some medications, such as anti-cancer drugs and medications used for Parkinson’s disease. Another use for Vomistop is to increase breast milk production, as a side effect of its intended use.
How does Vomistop work?
Vomistop 10 contains domperidone, a dopamine antagonist that acts as an antiemetic (prevents nausea and vomiting) and as a gastrokinetic (stimulates gastrointestinal mobility). Nausea and vomiting are triggered when the chemoreceptor trigger zone (CTZ) in the brain is stimulated, and this causes nerve impulses to be sent to area postrema or vomiting centre of the brain, to induce the vomiting reflex. The CTZ can be activated by two mechanisms; either indirectly by transmission of nerve impulses sent to the brain from the stomach when it has been irritated, or directly by chemicals or drugs that are circulating in the blood and stimulate receptors in the brain. Vomistop 10 works by blocking the action of the chemical messenger dopamine and this stops the transmission of messages from the irritated or upset stomach to the brain, preventing the brain triggering the vomiting response. Vomistop 10 also blocks the same chemical messengers in the upper digestive system. This relieves dysmobility, which is when food processing slows down causing uncomfortable symptoms. Vomistop 10 restores the natural rhythm of muscle contraction and relaxation in the stomach, which helps push food through the digestive system and prevents vomiting.
What does Vomistop contain?
Vomistop tablets 10mg contain the active ingredient domperidone, an antiemetic used to relieve nausea and vomiting.
Inactive ingredients: lactose, maize starch, microcrystalline cellulose, pregelatinised potato starch, povidone, magnesium stearate, hydrogenated cottonseed oil, sodium lauryl sulfate, hypromellose, and purified water.
Treating nausea and vomiting with Vomistop
Vomistop tablets 10mg contain domperidone, a dopamine antagonist that is used as antiemetic (prevents nausea and vomiting) to treat nausea and vomiting caused by a variety of conditions, including, gastrointestinal disorders or medication such as anti-cancer drugs. Vomistop 10 works by blocking the action of the chemical messenger dopamine in the brain and in the upper intestine, and this prevents vomiting and restores the natural rhythm of the digestive system. The action of Vomistop 10 helps relieve symptoms of digestive problems including bloating, fullness, heartburn, regurgitation of bile, abdominal pain and flatulence, which can happen when the digestive system is out of rhythm and cause discomfort.
How does Vomistop help with breastfeeding?
If you are having trouble producing enough breast milk you can use Vomistop to help with breastfeeding. Domperidone 10mg, the active ingredient of Vomistop, increases blood levels of the hormone prolactin, which stimulates milk production in a new mother’s breast cells. This is an indirect result of blocking the chemical messenger dopamine, which is also how Vomistop prevents nausea and vomiting. Vomistop does pass from the blood into breast milk, however, it is present in small amounts and there is no indication that it will harm the baby. Vomistop has fewer side effects than metoclopramide, which is another medication used for stomach problems that also stimulates milk production.
Vomistop for increasing breast milk production
Vomistop can be used to increase breast milk production as it has been found to increase blood levels of the hormone prolactin, which stimulates milk production in a new mother’s breast cells. This is an indirect result of blocking the chemical messenger dopamine, which is also how Vomistop prevents nausea and vomiting. Vomistop 10 does pass from the blood into your breast milk, however, it is present in small amounts and there is no indication that it will harm the baby. Vomistop has fewer side effects than metoclopramide, which is another medication used for stomach problems that also stimulates milk production.
What are the side effects of Vomistop?
The most commonly reported side effects when taking Vomistop 10 include: headache, abdominal cramps and dry mouth. Because Vomistop does not cross the blood brain barrier it does not cause what are known as extrapyramidal side effects, like convulsion and involuntary muscle actions that can be associated with some dopamine blocking medications. However, for the same reason Vomistop can increase the production of the hormone prolactin, which stimulates breast milk secretion, and this can cause breast enlargement (gynaecomastia) and temporary stoppage of periods (amenorrhoea). These side effects will stop as soon as you stop taking Vomistop.
When should Vomistop not be used?
You should not use Vomistop 10 if you:
- are allergic to to domperidone or any of the other components in Vomistop 10
- have an intolerance to lactose, a lactose malabsorption or a genetic disorder leading to accumulation of galactose in the blood (galactosaemia), as lactose is used to coat the tablets
- have a condition where increasing gut motility could be harmful, such as gastrointestinal haemorrhage, mechanical obstruction or a perforation
- have a kidney or liver condition than causes impairment of renal or hepatic function
- have a pituitary tumour that causes over-production of prolactin (prolactinoma)
- are taking another medication that may interact with Vomistop and prevent one or both drugs working effectively, such as the antifungals ketoconazole, fluconazole or voriconazole, antibiotics containing erythromycin, clarithromycin or telithromycin; amiodarone for rapid heart beat.
How should Vomistop be taken?
You should take Vomistop tablets 10mg swallowed whole with a glass of water 15 to 30 minutes before meals. If you are over 16, you can take a tablet three times a day and at bedtime, if necessary.
To increase breastmilk the usual dosage recommended by lactation consultants is up to TWO tablets FOUR times a day.
The dose you take and for how long depends on what you are being treated for and your doctor’s recommendation.
How long should you take Vomistop?
You should continue to take Vomistop 10 for as long as recommended by your doctor.
Missed dose of Vomistop
If you miss a dose of Vomistop 10, take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.
How should Vomistop be stored?
You should store your Vomistop tablets 10mg below 30°C in a cool dry place and protect from light.
Product Description
Vomistop Tablet is used in the treatment of indigestion, nausea, and vomiting. It increases the movement of food through the stomach and intestines, thereby relieving bloating, fullness, and gastric discomfort.
Take Vomistop Tablet half an hour before each meal in the dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should take this medicine until your doctor tells you to stop. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine.
The most common side effects are headache, dry mouth, and stomach pain. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. It may also cause dizziness. Do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen the side effects. This medicine may also cause diarrhea, so it is better to take plenty of fluids while taking this medicine as it may help to prevent dehydration.
Before taking this medicine you should let your doctor know if you have liver or kidney problems. You shouldn’t take it at the same time as an antacid. Pregnant women should also consult their doctor. You should avoid this medicine if suffering from bleeding ulcers in the stomach.
USES OF VOMISTOP TABLET
- Treatment of Indigestion
- Treatment of Nausea
- Treatment of Vomiting
BENEFITS OF VOMISTOP TABLET
In Treatment of Indigestion
Indigestion means discomfort of mainly the upper part of your stomach which may also have other symptoms such as stomach pain, bloating, feeling full, etc. Vomistop Tablet improves the movement of food in your stomach and gut (intestine). This relieves these symptoms and helps in the proper digestion of food.
Take Vomistop Tablet as prescribed by the doctor. Think about what foods trigger indigestion and try to avoid them; eat smaller, more frequent meals; try to lose weight if you are overweight, and try to find ways to relax. Do not eat within 3-4 hours of going to bed.
SIDE EFFECTS OF VOMISTOP TABLET
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Vomistop
- Headache
- Dryness in mouth
- Stomach pain
- Diarrhea
HOW TO USE VOMISTOP TABLET
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Vomistop Tablet is to be taken empty stomach.
HOW VOMISTOP TABLET WORKS
Vomistop Tablet is a prokinetic. It works on the region in the brain that controls vomiting. It also acts on the upper digestive tract to increase the movement of the stomach and intestines, allowing food to move more easily through the stomach.